In a large stock pot, cook macaroni according to package directions and drain. Set aside to keep warm.
In a dutch oven, add butter and flour and cook over medium heat, whisking constantly until a thick roux forms. Carefully stir in milk and whipping cream and continue to whisk and heat until hot and smooth. Pour in cheddar and Parmesan cheeses and spices and continue to stir until all cheese is melted. Fold in macaroni.
Remove from heat and top with panko. Bake for 20 minutes. Remove from oven and serve hot.