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Preheat oven to 350 and line a 9x13 baking pan with parchment paper, making sure it comes up the sides. Spray with nonstick cooking spray and set aside.
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Add flour, sugar and 2 sticks of cubed butter to a food processor. Process for 10 seconds or until a fine crumbly texture has formed. Pour into prepared pan and use the back of spoon to press evenly into the pan. Bake for 10 minutes.
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Add cream cheese, sugars and flour to a mixer and beat well until combined. Add lemon juice, eggs, vanilla and lemon zest and beat until combined well.
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Pour on top of crust and bake for 50-55 minutes or until edges begin to brown and center is set. Cool for 1 hour in the pan and then refrigerate for 4 hours. Remove from refrigerator and remove from pan by lifting out the paper. Gently peel away paper and sprinkle with powdered sugar before cutting into bars.